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All you need for a plague to go pandemic are population clusters and travellers spreading the bacterial or viral pathogens. Plague in Athens killed 30% of the population 430-426 BCE. When Roman Emperor Justinian I caught bubonic plague in 541 CE, contemporary historian Procopius described his symptoms: fever, delirium and buboes -large black swellings of the lymphatic glands in the groin, under the arms and behind the ears.
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